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Table 2 Updating methods for multinomial logistic regression models with the numbers of parameters that are estimated for updating in general and in the case study

From: Validation and updating of risk models based on multinomial logistic regression

Category Method and description Number of parameters
(General = case study)
Original 0—no adjustments 0 = 0
Recalibration 1—intercept recalibration: adjust intercepts (k − 1) = 2
2—logistic recalibration: adjust intercepts and slopes k × (k − 1) = 6
  3—refitting: re-estimation of individual coefficients (q + 1) × (k − 1) = 8
Revision 4—penalized refitting using recalibrated coefficients from method 2 as offset (k + q + 1) × (k − 1) = 14
  5—refitting including functional form: method 3, but hCGr modeled with rcs (q′ + 1) × (k − 1) = 8
Extension 6—extension: similar to method 3 but log(progesterone) added (q + m + 1) × (k − 1) = 10
7—penalized extension: similar to method 5 but log(progesterone) added (k + q + m + 1) × (k − 1) = 16
  1. hCGr human chorionic gonadotropin ratio, rcs restricted cubic spline, k number of outcome categories, q number of variables (including additional nonlinear and interaction terms, but excluding intercepts) in original model, q ′ number of variables when changing functional form of one or more predictors, m number of variables related to added markers