Value-based and benefit-based strategies in deciding to bring a test into use should be distinguished

Table 1 Some examples for the impact of the results of one enrichment design study and/or one interaction study on the time where the test is in use following BBS or VBS, respectively

Test number	Enrichment design study	Interaction design study		Time interval of test use under
	\({\hat \theta ^{T}_{+}}\)	\({\hat \theta ^{T}_{-}}\)	\({\hat \theta ^{T}_{+}}\)	bbs	vbs
1	0.41 [0.11, 0.51] ^a	–0.21 [–0.39, –0.03] ^a	0.57 [0.39, 0.75] ^a	E- ∞	I- ∞
2	0.54 [0.29, 0.78] ^a	0.23 [0.01, 0.44] ^a	0.39 [0.17, 0.52] ^a	E-I	never
3	0.66 [0.34, 0.99] ^a	0.11 [–0.21, 0.43]	0.47 [0.13, 0.82] ^a	E- ∞	never
4	0.29 [0.07, 0.51] ^a	–		E- ∞	never
5	–	–0.32 [–0.57, –0.06] ^a	0.71 [0.56, 0.95] ^a	I- ∞	I- ∞
6	–	–0.07 [–0.43, 0.57]	0.53 [0.07, 0.99] ^a	I- ∞	never

Treatment effects are expressed as log relative risks for treatment success with 95% confidence intervals.
^aLog RR significant different from 0 at the 5% level. E and I refer to the time points of the enrichment and the interaction study

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