|
Age (per 1 year increase)
|
1.041
|
(1.017, 1.066)
|
<.001
|
|
Gender, female (vs. male)
|
0.767
|
(0.481, 1.225)
|
0.27
|
|
Race, White (vs. non-White)
|
0.901
|
(0.587, 1.385)
|
0.22
|
|
Glycemic arm treatment, insulin providing (vs. insulin sensitizing)
|
0.885
|
(0.613, 1.276)
|
0.51
|
|
History of insulin use
|
1.472
|
(0.984, 2.200)
|
0.06
|
|
History of MI
|
0.708
|
(0.476, 1.054)
|
0.09
|
|
History of CHF
|
2.699
|
(1.361, 5.350)
|
0.005
|
|
Hypertension
|
1.433
|
(0.818, 2.508)
|
0.21
|
|
Hypercholesterolemia
|
0.655
|
(0.431, 0.995)
|
0.047
|
|
Cerebrovascular accident, TIA
|
1.591
|
(0.892, 2.840)
|
0.12
|
|
Prior revascularization
|
1.482
|
(0.929, 2.362)
|
0.10
|
|
Current smoker
|
0.997
|
(0.548, 1.815)
|
0.99
|
|
Angina equivalent
|
1.055
|
(0.724, 1.537)
|
0.78
|
|
Angina class (vs. no angina)
|
|
Stable 1, 2
|
0.831
|
(0.560, 1.232)
|
0.85
|
|
Stable 3, 4
|
1.291
|
(0.632, 2.637)
|
0.49
|
|
Unstable
|
1.230
|
(0.526, 2.879)
|
0.23
|
|
Weight (kg) (per 1 year increase)
|
1.000
|
(0.990, 1.011)
|
0.94
|
|
BMI (per 1 unit increase)
|
0.993
|
(0.957, 1.031)
|
0.73
|
|
Systolic blood pressure (per 1 unit increase)
|
1.008
|
(1.000, 1.017)
|
0.05
|
|
Diastolic blood pressure (per 1 unit increase)
|
0.996
|
(0.978, 1.015)
|
0.69
|
|
Ankle brachial index (per 1 unit increase)
|
0.899
|
(0.416, 1.943)
|
0.79
|
|
Serum creatinine (mg/dl) (per 1 unit increase)
|
2.679
|
(1.399, 5.128)
|
0.003
|
|
Urine albumin/creatinine ratio mg/g, (per 100 unit increase)
|
1.041
|
(1.020, 1.063)
|
<.001
|
|
Circulating insulin (IU/ml) (per 1 unit increase)
|
1.015
|
(1.002, 1.029)
|
0.023
|
|
HbA1c (%) (per 1 unit increase)
|
1.057
|
(0.949, 1.178)
|
0.32
|
|
HDL cholesterol (mg/dl) (per 1 unit increase)
|
0.986
|
(0.967, 1.006)
|
0.16
|
|
LDL cholesterol (mg/dl) (per 1 unit increase)
|
0.998
|
(0.992, 1.004)
|
0.50
|
|
Triglycerides (mg/dl) (per 1 unit increase)
|
0.976
|
(0.837, 1.139)
|
0.76
|
|
Myocardial jeopardy (per 1 unit increase)
|
1.012
|
(1.003, 1.021)
|
0.007
|
|
Non-sublingual nitrate
|
1.130
|
(0.767, 1.666)
|
0.54
|
|
Anti-platelet
|
1.168
|
(0.705, 1.935)
|
0.55
|
|
Aspirin
|
1.057
|
(0.593, 1.885)
|
0.85
|
|
Statin
|
1.108
|
(0.710, 1.729)
|
0.65
|
|
ACE/ARB
|
1.160
|
(0.722, 1.864)
|
0.54
|
|
Beta-blocker
|
0.837
|
(0.554, 1.265)
|
0.40
|
|
Aspirin, statin, ACE/ARB, beta-blocker
|
1.248
|
(0.865, 1.801)
|
0.24
|